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MEDICATION SAFETYPain relief with kidneydisease: avoid NSAIDs1Common NSAIDs: ibuprofen, diclofenac, naproxen,mefenamic acid, celecoxib, and aspirin at pain-reliefdoses. Many combination cold remedies contain themtoo.2KDIGO guidance: avoid NSAIDs when eGFR is below 30;no prolonged use when eGFR is below 60.3The "triple whammy": an NSAID plus an ACEinhibitor/ARB plus a diuretic clearly raises the riskof acute kidney injury.4Risk is higher when you are ill and dehydrated(vomiting, diarrhoea, fever) — ask your doctor whichmedicines to pause on sick days.5For occasional pain, acetaminophen (paracetamol)within the recommended dose is usually the saferchoice — but still ask first; patches and gels areabsorbed too.Before buying any painkiller, ask the pharmacist one question: "I havekidney disease — is this safe for me?"BBeyond CKDbeyondckd.com/de/cards/painkillers-and-kidneysSources: KDIGO 2024 CKD Guideline · KDIGO 2012 CKD Guideline · 2026-10-16Compiled from public clinical guidelines · General education, not individual medical advice
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Medication safety

Pain relief with kidney disease: avoid NSAIDs

Headache — grab any painkiller? With kidney disease, check which kind first.

  1. 1Common NSAIDs: ibuprofen, diclofenac, naproxen, mefenamic acid, celecoxib, and aspirin at pain-relief doses. Many combination cold remedies contain them too.
  2. 2KDIGO guidance: avoid NSAIDs when eGFR is below 30; no prolonged use when eGFR is below 60.
  3. 3The "triple whammy": an NSAID plus an ACE inhibitor/ARB plus a diuretic clearly raises the risk of acute kidney injury.
  4. 4Risk is higher when you are ill and dehydrated (vomiting, diarrhoea, fever) — ask your doctor which medicines to pause on sick days.
  5. 5For occasional pain, acetaminophen (paracetamol) within the recommended dose is usually the safer choice — but still ask first; patches and gels are absorbed too.

Before buying any painkiller, ask the pharmacist one question: "I have kidney disease — is this safe for me?"

Bildunterschrift (direkt einfügbar)

Headache — grab any painkiller? With kidney disease, check which kind first.

1. Common NSAIDs: ibuprofen, diclofenac, naproxen, mefenamic acid, celecoxib, and aspirin at pain-relief doses. Many combination cold remedies contain them too.
2. KDIGO guidance: avoid NSAIDs when eGFR is below 30; no prolonged use when eGFR is below 60.
3. The "triple whammy": an NSAID plus an ACE inhibitor/ARB plus a diuretic clearly raises the risk of acute kidney injury.
4. Risk is higher when you are ill and dehydrated (vomiting, diarrhoea, fever) — ask your doctor which medicines to pause on sick days.
5. For occasional pain, acetaminophen (paracetamol) within the recommended dose is usually the safer choice — but still ask first; patches and gels are absorbed too.

Before buying any painkiller, ask the pharmacist one question: "I have kidney disease — is this safe for me?"

Quellen: KDIGO 2024 CKD Guideline — Ch. 4 (medication safety, NSAIDs, sick-day guidance); KDIGO 2012 CKD Guideline — Rec. 4.4 (NSAIDs: avoid at GFR <30; no prolonged use at GFR <60); Lapi F et al. NSAIDs + diuretics + ACEi/ARB and acute kidney injury — BMJ 2013;346:e8525; NKF — Pain Medicines (Analgesics) and the kidneys
Geprüft am: 2026-10-16

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https://beyondckd.com/de/cards/painkillers-and-kidneys
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Sek.BildVoice-over
0–5Hand reaching for painkillers on a pharmacy shelfHeadache, grab a painkiller? If you have kidney disease, wait a second.
5–17Drug list: ibuprofen, diclofenac, naproxen…Many common painkillers are NSAIDs — ibuprofen, diclofenac, naproxen — and plenty of cold remedies contain them. They reduce blood flow to the kidneys.
17–28"eGFR <30 avoid | <60 no long-term use"KDIGO guidelines say: avoid NSAIDs if eGFR is below 30, and no long-term use below 60.
28–40Three pills colliding: NSAID + ACEi/ARB + diuretic → ⚠️Watch out for the triple whammy: an NSAID plus a blood-pressure drug like an ACE inhibitor or ARB, plus a diuretic — acute kidney injury risk goes up clearly.
40–50Sick person icon, "ask your doctor"The risk is higher when you are ill and dehydrated. Vomiting, diarrhoea, fever — ask your doctor which medicines to pause.
50–60Pharmacy counter speech bubble + site logo + QRFor occasional pain, acetaminophen within the recommended dose is usually safer. But always ask: I have kidney disease — is this OK for me? More at Beyond CKD.

Quellen (jeder Punkt auf der Karte lässt sich zuordnen)

Geprüft am: 2026-10-16